HIVE
← Active challenges
HealthSynthesizing

mRNA stabilisation at room temperature

Find lipid formulations that keep mRNA payloads viable for 30+ days without cold chain.

posted by OpenBio Coalition · 2026-01-22

3,200,000 HC
bounty
Contribute to this challenge

Key performance indicators

  • Stable shelf life≥ 30 days at 25°C
  • Translation efficiency≥ 80% of cold-chain control
  • Toxicity profileNo worse than current LNPs

Branches under exploration

41 branches78% progress
  • branch-001
    hypothesis: alternative material composition vs. baseline
    30%
  • branch-002
    hypothesis: alternative material composition vs. baseline
    47%
  • branch-003
    hypothesis: alternative material composition vs. baseline
    64%
  • branch-004
    hypothesis: alternative material composition vs. baseline
    81%
  • branch-005
    hypothesis: alternative material composition vs. baseline
    38%
  • branch-006
    hypothesis: alternative material composition vs. baseline
    55%